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JAMA Network Open Publication: Association of Early Antibiotic Exposure With Childhood Body Mass Index Trajectory Milestones

The manuscript, “Association of Early Antibiotic Exposure With Childhood Body Mass Index Trajectory Milestones,” was recently published on JAMA Network Open.

Authors who contributed to this research include: Izzuddin M. Aris, PhD; Pi-I D. Lin, ScD; Sheryl L. Rifas-Shiman, MPH; L. Charles Bailey, MD, PhD; Janne Boone-Heinonen, PhD, MPH; Ihuoma U. Eneli, MD, MS; Anthony E. Solomonides, PhD, MMath; David M. Janicke, PhD; Sengwee Toh, ScD; Christopher B. Forrest, MD, PhD; Jason P. Block, MD. CAPriCORN’s NorthShore University Health System Site Member Anthony Solomonides, PhD, MSc(Math), MSc(AI), FAMIA, worked on the analysis of trajectories.

Key Points

Question
Is early antibiotic exposure associated with altered body mass index (BMI) trajectory milestone patterns in childhood?

Findings
This cohort study of 183 444 children identified small associations with age and magnitude of BMI at peak in infancy and rebound in early childhood after antibiotic exposure before 48 months of age.

Meaning
The findings of this study suggest these small associations with BMI trajectory milestones after early-life antibiotic exposure should not affect the individual decision to prescribe antibiotics.

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